Kibar Yared, MD, FRCPC

  • Cardiac Ultrasound Laboratory
  • Massachusetts General Hospital
  • Boston, Massachusetts

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Epoetin given to laboratory animals during pregnancy caused birth defects in the tested species symptoms ulcerative colitis 250 mg antabuse amex, including damage to the bones and spine. The drug, however, has not been reported to cause problems in human babies whose mothers took it during pregnancy. Nevertheless, women who are or may become pregnant should check with their physicians for the most up-to-date information on the safety of taking this medicine during pregnancy. For example, there appears to be a greater risk of side effects in people with high blood pressure, disorders of the heart or blood vessels, or a history of blood clots. In addition, epoetin may not work properly in people who have bone disorders or sickle cell anemia. Interferons Interferons may intensify the effects of alcohol and other drugs that slow down the central nervous system, including antihistamines, over-the-counter cold medicines, allergy medications, sleep aids, anticonvulsants, tranquilizers, some pain relievers, and muscle relaxants. Interferons may also intensify the effects of anesthetics, including the local anesthetics used for dental procedures. Patients taking interferons should consult their physicians before taking any of these medications. The medicine may also increase the risk of seizures (convulsions) in people with epilepsy or other seizure disorders. Getting prompt treatment for infections is important, even while the patient is taking these medications. Patients taking colonystimulating factors should call their physician at the first sign of illness or infection, including a sore throat, fever, or chills. People with certain medical conditions may have problems if they take colony-stimulating factors. Patients with kidney disease, liver disease, or conditions related to inflammation or immune system 2646 Some people experience dizziness, unusual fatigue, or drowsiness while taking these drugs. Because of these possible problems, anyone taking these drugs should not drive, use heavy machinery, or do anything else that requires full alertness until they have determined how the drugs affect them. The prescribing physician may recommend taking acetaminophen (Tylenol) before-and sometimes after-each dose to keep the fever from getting too high. If the physician recommends taking acetaminophen, the patient should follow his or her instructions carefully. Like aldesleukin, interferons may temporarily increase the risk of getting infections and lower the number of platelets in the blood, which may lead to clotting problems. Patients should observe these precautions for reducing the risk of infection and bleeding for aldesleukin. People who have certain medical conditions may have problems if they take interferons.

Syndromes

  • Mastoiditis
  • Not cancer (benign) or thyroid cancer
  • Incontinence
  • Pneumonia
  • Difficulty swallowing
  • Swollen belly
  • Genetic studies
  • Uncontrollable eye movement (nystagmus)
  • Irritable bowel syndrome

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The affected person is placed in contact with a waterfilled cushion (older machines require that the individual is actually seated in a tub of water) medicine wheel colors generic antabuse 250 mg online. The shock waves are created and focused with the help of a machine called a C-Arm Image Intensifier. The resulting debris, called gravel, can then pass through the remainder of the ureter, through the bladder, and through the urethra during urination. There is minimal chance of damage to skin or internal organs because biologic tissues are resilient, not brittle, and because the shock waves are not focused on them. The shock wave is characterized by a very rapid pressure increase in the transmission medium and is quite different from ultrasound. At the edge of the stone, energy is transferred into the stone, 3031 Description Lithotripsy uses the technique of focused shock waves to fragment a stone in the kidney or the ureter. Eventually, the stone is reduced to small particles, which are then flushed out of the kidneys or ureter naturally during urination. After obtaining an x-ray of the lower abdomen, a radiopaque dye is injected into the veins. Kidney stone-A hard mass that forms in the urinary tract that can cause pain, bleeding, obstruction, and/or infection. Ultrasound-A diagnostic imaging modality that uses sound waves to determine internal structures of the body. Preparation Prior to the lithotripsy procedure, a complete physical examination is performed, followed by tests to determine the number, location, and size of the stone or stones. This dye, which shows up on x-ray, travels through the bloodstream and is excreted by the kidneys. In this manner, x-rays are used to evaluate the stones and the anatomy of the urinary system. For women of childbearing age, a pregnancy test is done to make sure they are not pregnant. Lots of fluids should be taken to encourage the flushing of any gravel remaining in the urinary system. Treated persons should follow up with a urologist in about two weeks to make sure that everything is progressing as planned. Other problems may include perirenal hematomas (blood clots near the kidneys) in 66% of the cases, nerve palsies, pancreatitis (inflammation of the pancreas), and obstruction by stone fragments. Death is extremely rare and usually due to an undiagnosed associated or underlying condition that is aggravated by the lithotripsy procedure. However, persistent or severe abdominal pain may imply an unexpected internal injury. For these people, focused sound waves, called ultrasound, can be used to identify where the stones are located. This approach is uncommon today, but occasionally used when other conditions prevent the use of lithotripsy.

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More than 100 clinical trials are enrolling patients with various types of kidney disease medicine grapefruit interaction generic 250 mg antabuse with mastercard. Leading causes are diabetes, high blood pressure, inherited disease, and infection. Acute kidney disease is often marked by a lack of urination and increased fluid build up in the body. Chronic kidney disease is often called a 'silent' killer, because no obvious symptoms develop until the kidneys are permanently damaged. The National Kidney Foundation estimated in 2014 that 26 million Americans had undetected moderate chronic kidney disease. Chronic kidney disease most often results from other diseases such as diabetes or hypertension. Diagnosis Simple blood and urine tests can indicated kidney disease, but more extensive testing may be needed to determine the exact nature of the disease. A blood test that measures serum creatinine, a waste product, can indicate how well the kidneys are working. A 24-hour urine collection test will accurately measure how much urine the kidneys are producing in a day. A urinalysis can determine if protein or red blood cells are leaking into the urine indicating abnormal kidney function. A creatinine clearance test compares the amount of creatinine in a 24-hour urine sample with the amount of creatinine in the blood to determine how much blood the kidneys are filtering each minute. Glomerulous-A twisted mass of blood capillaries and urine tubules in the kidney where filtering of waste products occurs. Hormone-A chemical produced by living cells that travels through the circulatory system and affects tissue at some distance from where it was released. Nephron-The smallest functional unit of the kidney involved in the removal of waste products and excess water from the blood. Alternatives Alternative treatments tend to focus on removing excess water from the body, but have limited effect on serious disease. Asparagus (Asparagus officinalis) birch tea (Betula species), goldenrod infusion (Solidago species), horsetail (Equisetum arvense), and stinging nettle (Urtica dioica) all are used to stimulate urine production. Prognosis Many individuals recover normal kidney function after developing acute kidney disease, although in some cases, such as poisoning and injury, kidney damage may be permanent. More than 15,000 kidney transplants are done each year, and there is a often long waiting list for donated kidneys. Controlling underlying diseases such as diabetes and high blood pressure are important in preventing chronic kidney diseases. A doctor who orders kidney function tests and uses the results to assess the functioning of the kidneys is called a nephrologist. Approximately one and a half quarts of blood per minute are 2853 American Association of Kidney Patients, 3505 E. Kidney function tests help to determine if the kidneys are performing their tasks adequately.

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Symptoms are persistent and frequent infections symptoms for bronchitis purchase 250mg antabuse mastercard, diarrhea, failure to thrive, and malabsorption (of nutrients). Prognosis Patients with immunoglobulin deficiency syndromes must practice impeccable health maintenance and care, paying particular attention to optimal dental care, in order to stay in good health. Prevention There is not a known way to prevent immunoglobulin deficiency syndromes. The profile of organisms that cause infection in patients with immunoglobulin deficiency syndrome is unique 2644 Abbas, Abul K. Description Most drugs in this category are synthetic versions of substances produced naturally in the body. Longe Immunoglobulin electrophoresis see Immunoelectrophoresis Immunoglobulins G, A, and M test see Immunoelectrophoresis Aldesleukin (Proleukin) is an artificial form of interleukin-2, which helps white blood cells work. Aldesleukin is administered to patients with kidney cancers and skin cancers that have spread to other parts of the body. Filgrastim (Neupogen) and sargramostim (Leukine) are versions of natural substances called colonystimulating factors, which encourage the bone marrow to make new white blood cells. Epoetin (Epogen, Procrit) is a synthetic version of human erythropoietin, which stimulates the bone marrow to make new red blood cells. Thrombopoietin stimulates the production of platelets, which are disk-shaped bodies in the blood that are important in clotting. Interferons are substances that the body produces naturally, using cells in the immune system to fight infections and tumors. Some of the interferons that are currently in use as medications are recombinant interferon alfa-2a, recombinant interferon alfa-2b, interferon alfa-n1, and interferon alfa-n3. Interferons are also used to treat conditions such as laryngeal papillomatosis, genital warts, and certain types of hepatitis. Patients who are taking drugs that can be used at home should consult the prescribing physician or their pharmacist for the correct dosage. Most of these drugs come in an injectable form, which is generally administered by a cancer care provider. Taking the following precautions may reduce the chance of such complications: Avoid people with infectious diseases whenever possible. Be alert to such signs of infection as fever, chills, sore throat, pain in the lower back or side, cough, hoarseness, or painful or difficult urination. Be alert to such signs of bleeding problems as black or tarry stools, tiny red spots on the skin, blood in the urine or stools, or any other unusual bleeding or bruising. Take care to avoid cuts or other injuries, particularly when using knives, razors, nail clippers, and other sharp objects. The patient should consult his or her dentist for the best ways to clean the teeth and mouth without injuring the gums. In addition, patients should not have any dental work done without checking with their primary physician.

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Preparation Emptying the bowel with laxatives or enemas prevents bowel shadows from obscuring the details of the urinary system medicine 853 cheap antabuse 250 mg mastercard. An empty stomach prevents the complications of vomiting, a rare effect of the contrast agent. Just as fast as the onset of pain appears, it disappears and the child resumes activity normally. This process of sudden severe abdominal pain appearing out of the blue then disappearing is repeated with duration of painful attacks. The pain usually increases after approximately five hours of recurrent cycles of severe abdominal pain followed by relaxation. Physical examination and palpation usually reveal a sausage shaped mass of enfolded bowel in the right upper mid portion of the abdomen. Within a few hours approximately 50% of cases have bloody, mucus filled bowel movements. At about this time the child is visibly very ill with fever, tenderness, and distended abdomen. The remaining 15% of cases can be caused by a variety of other diseases such as tumors of the lymph nodes (lymphoma), fat tumors (lipomas), foreign bodies/ objects, or from infections that mobilize immune cells to the area causing an inflammatory reaction and intestinal blockage. Most cases of intussusception do not strangulate the affected bowel within the first 24 hours. If the disease is not treated after this time, the possibility of intestinal gangrene, shock, and death increases. Anyone with a possible iodine allergy or a previous reaction to x-ray dye must be particularly careful to inform the x-ray personnel. It is characterized and initially presents with recurring attacks of cramping abdominal pain that gradually become more painful. Description Intussusception occurs when part of the bowel or intestine is wrapped around itself producing a masslike object on the right side of the abdomen during 2782 the major symptom of intussusception is when a healthy child suddenly and without warning experiences severe abdominal pain that subsides and usually results in continuation of normal activities such as playing. Usually, the child develops nausea, vomiting, and diarrhea soon afterwards in about 90% of all cases. These blood filled bowel movements are usually due to impaired blood flow to the obstructed area. During palpation there may be a sausage-shaped mass located on the upper right mid portion of the abdomen. Intussusception of the bowel results in the bowel telescoping onto itself (A and B). If the surgeon cannot manipulate the bowel into a normal shape manually, the area of intussusception will be removed and remaining bowel sutured together (D). Additionally, there may be perforation or a hole in the intussusception bowel that can cause a life threatening infection in the peritoneum (a layer of tissue that protects the organs and intestines within the abdominal cavity).

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It is caused when mothers drink heavily during the first 12 weeks (trimester) of pregnancy symptoms weight loss purchase antabuse 250 mg on-line. Some studies have shown that even moderate alcohol use during pregnancy may cause learning disabilities in children. Drug abuse and cigarette smoking during pregnancy have also been linked to intellectual disability. A neural tube defect, for example, is a birth defect in which the neural tube that forms the spinal cord does not close completely. This defect, which occurs with varying levels of severity, may cause children to develop an accumulation of cerebrospinal fluid inside the skull (hydrocephalus). The pressure on the brain resulting from hydrocephalus can lead to changes that cause learning impairment. Hyperthyroidism, whooping cough, chicken pox, measles, and Hib disease (a bacterial infection caused by Haemophilus influenzae type B) may cause intellectual disability if they are not treated adequately. Neglected infants who are not provided with the mental and physical stimulation required for normal development may irreversible learning impairment. The disorder may be caused by an inherited genetic abnormality, such as fragile X syndrome. Cytogenetics-The branch of genetics concerned with the structure and function of the individual cell, particularly its chromosome content. Stigma-Any personal attribute that causes a person to be socially shamed, avoided, or discredited. A complete medical, family, social, and educational history is compiled from existing medical and school records (if applicable) and from interviews with parents. Schoolchildren are given intelligence tests to measure their learning abilities and intellectual functioning. Such tests include the Stanford-Binet Intelligence Scale, the Wechsler Intelligence Scales, the Wechsler Preschool and Primary Scale of Intelligence, and the Kaufman Assessment Battery for Children. For infants, the Bayley Scales of Infant Development may be used to assess motor, language, and problem-solving skills. Procedures Recent advances in cytogenetics and microscopy have made the detection of chromosomal abnormalities after birth much more accurate. The cells are cultured in the laboratory and prepared for examination under a microscope by one of several purification, preservation, and staining techniques. Analysis of the chromosomes in the cell must be done by a board-certified specialist in cytogenetics.

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The patient is typically required to wear a hospital gown or similar attire and to remove all jewelry so the x-ray camera has an unobstructed view of the abdomen treatment keratosis pilaris purchase antabuse 250 mg mastercard. A lead apron may be placed over the abdominal areas of the body not being x-rayed to shield the patient from unnecessary radiation. Purpose Kinesiology claims to be a healing system that detects and corrects imbalances in the body before they develop into a disease, and which restores overall system balance and harmony. It is used to alleviate muscle, bone, and joint problems, treat all manner of aches and pains, and correct many areas of imbalance and discomfort. Precautions Since interpretation of the muscle tests is both complex and subjective, it should only be performed by a licensed health professional trained to look for 'subclinical' symptoms (those which have not yet become a major problem). Kinesiology, itself, is more of a diagnostic technique and should not be thought of as a cure for any particular problem. Goodheart founded what has become known as applied kinesiology when he linked oriental ideas about energy flow in the body with western techniques of muscle testing. He observed that for each movement a muscle makes, there is another muscle or group of muscles involved with that movement; one muscle contracts while another one relaxes. So when he was presented with a painful, overly-tight muscle, he would observe and treat the opposite, and necessarily weak, muscle to restore balance. Further, Goodheart argued that there is a definite and real connection between muscles, glands, and organs, and that by testing the strength of certain muscles he could learn about the health or condition of the gland or organ to which it was related. Applied kinesiology is based on the idea that the body is an interacting unit made of different parts that interconnect and affect each other. Everything we do affects the body as a whole; therefore, a problem in one area can cause trouble in another area. According to kinesiology, the muscles eventually register and reflect anything that is wrong with any part of the body, whether physical or mental. Thus, a particular digestive problem might show up in the related and corresponding muscles of the legs. The manual testing of muscles or muscle strength is not new, and was used in the late 1940s to evaluate muscle function and strength and to assess the extent of an injury. Applied kinesiology measures whether a muscle is stuck in the 'on' position, acting like a tense muscle spasm, or is stuck 'off,' appearing weak or flaccid. Spasm-An involuntary, sudden, violent contraction of a muscle or a group of muscles. Patients are asked to resist this pressure, and, if they cannot, an imbalance is suspected in the related organ, gland, or body part.

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Because of this connection between accommodation and convergence symptoms rectal cancer buy antabuse 500 mg without prescription, if the lens needs to accommodate to focus for distance (to bring the image back onto the retina) the eyes may appear to turn in even when looking at the distance. Hyperparathyroidism Treatment the usual treatment for hyperopia is corrective lenses (spectacles or contact lenses). Although there have been many reports of success using different kinds of lasers to increase corneal curvature, there are still problems with stability and predictability. The introduction of light-activated biologic tissue glue in 1997 holds promise for improvements in those areas. Some combinations of these variables give rise to eyes where the cornea is too flat for the distance between the cornea and the retina. If the hyperopia is not too severe the lens may be able to accommodate and bring the image back onto the retina. This would result in clear distance vision, but the constant focusing might result in headaches or eyestrain. If the lens cannot accommodate for the full amount of the hyperopia the distance image would be blurry. If the eyes are focusing for distance and now the person is looking at a near object, the eyes need to accommodate further. Depending upon the amount of hyperopia, symptoms can range from none to clear distance vision but blurry near vision, to blurry distance and near vision. An eye turned in (esotropia) may be a result of hyperopia, particularly in children. However, because a turned eye may be a result of more serious causes it is very important to have it checked out. Prognosis the prognosis for fully corrected vision is excellent for patients with low to moderate amounts of hyperopia. Hyperopia increases the chances of chronic glaucoma, but vision loss from glaucoma is preventable. Prevention Hyperopia is usually present at birth, and there is no known way to prevent it. This is done with the use of eyedrops and is called a cycloplegic exam or cycloplegic refraction. The drops relax the accommodation (making reading blurry until the drops wear off). Patients will usually be asked to have someone drive them home because of the blurriness. Lorraine Lica, PhD Hyperparathyroidism Definition Parathyroid glands are four pea-sized glands located just behind the thyroid gland in the front of the neck. The function of parathyroid glands is to 2555 Hyperparathyroidism produce a hormone called parathyroid hormone (parathormone), which helps regulate calcium and phosphate in the body. Description Thyroid glands and parathyroid glands, despite their similar name and proximity, are entirely separate, and each produces hormones with different functions.

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Other surgeries are continuously improved upon to make biopsy less invasive and surgery more effective treatment in statistics cheap 250mg antabuse amex, such as video-assisted lobectomy. Other purposes for lung surgery may include severe abscess, areas of 3107 Lung surgery long-term infection, or permanently enlarged or collapsed lung tissue. Precautions Thoracotomy should not be performed on patients whose general health status will not tolerate major surgery. Any surgery carries with it risks associated with general anesthesia and possibility of infection. Patients whose risk for these complications outweighs benefit may not be considered candidates for lung surgery. In general, the surgery method chosen will depend on specific circumstances and consideration of benefit versus risk. Patients will receive instructions from a physician concerning limit of food or water intake prior to the surgery, as well as risks and expected recovery. Patients should continue to follow treatment for the underlying condition, unless instructed otherwise by the physician, and should discuss medications and changes in condition with their physician prior to the surgery. Description Lung surgery procedures will vary depending on the underlying cause of the surgical test or intervention. Following the surgery, drainage tubes may be placed in the chest to drain fluids, blood, and air from the chest cavity. It may often be indicated only when a lobectomy does not successfully remove the cancerous or damaged tissue. Thoracotomy consists of reaching the lung tissue through incision and obtaining tissue for a biopsy. The biopsy is used to diagnose or stage cancer, and thoracotomy may be avoided until other less invasive methods have failed. Volume reduction surgery involves incision and removal of those parts of the lung or lungs which are the most destroyed, in order to allow for full function of the remaining lung structure. Lobectomy is performed in the same general manner as other lung surgeries, but will involve removal of an entire lobe of the lung. Lobectomy may only be performed if a wedge or segmental resection is ineffective, but is generally preferred as treatment for primary lung cancer in any patient who can tolerate the procedure. Patients who do not have enough pulmonary function to undergo a lobectomy will receive a wedge 3108 Aftercare the chest tube inserted at the end of surgery will remain in place until the lung has fully expanded. Patients will be carefully monitored in the hospital for complications and infection. After discharge from the hospital, the patient may still receive some pain or infectionfighting medications and should recover within one to three months of the operation. Results Outcome for any lung surgery depends on many factors and the severity of disease. In general, the predicted benefits, which justified the surgery, are normal expected results.

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When combined with obesity medications list antabuse 250mg with amex, smoking, high cholesterol, or diabetes, the risk of heart attack or stroke increases several times. The risk of developing coronary artery disease is seriously increased for diabetics. Excess weight increases the strain on the heart and increases the risk of developing coronary artery disease, even if no other risk factors are present. Some scientists believe that stress and anger can contribute to the development of coronary artery disease. Stress increases the heart rate and blood pressure and can injure the lining of the arteries. Angina symptoms include: a tight, squeezing, heavy, burning, or choking pain that is usually beneath the breastbone-the pain may spread to the throat, jaw, or one arm a feeling of heaviness or tightness that is not painful a feeling similar to gas or indigestion attacks brought on by exertion and relieved by rest 2795 Causes and symptoms Ischemia is almost always caused by blockage of an artery, usually due to atherosclerotic plaque. Myocardial ischemia is also caused by blood clots (which tend to form on plaque), artery spasms or contractions, or any of these factors combined. Silent ischemia is usually caused by emotional or mental stress or by exertion, but there are no symptoms. Angina is usually caused by increased oxygen demand when the heart is working harder than usual-for example, during exercise, or during mental or physical stress. According to researchers at Harvard University, physical stress is harder on the heart than mental stress. It can reveal abnormalities in the heart wall that indicate ischemia, but it does not evaluate the coronary arteries directly. Coronary angiography is the most accurate diagnostic technique, but it is also the most invasive. The cardiologist then inserts a catheter into a blood vessel and guides it into the heart. Coronary angiography is performed in a cardiac catheterization laboratory and takes from half an hour to two hours. Performed at a hospital, it usually takes from one hour to one hour and 45 minutes. Another type of electrocardiogram, the exercise stress test, measures response to exertion when the patient is exercising on a treadmill or a stationary bike. Myocardial perfusion scintigraphy and radionuclide angiography are nuclear studies involving the injection of a radioactive material. Drugs such as nitrates, beta-blockers, and calcium channel blockers relieve chest pain, but they cannot clear blocked arteries. Surgical procedures include percutaneous transluminal coronary angioplasty and coronary artery bypass graft surgery. It quickly relieves pain and discomfort by opening the coronary arteries and allowing more blood to flow to the heart.

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Kayor, 62 years: The patient may experience an annoying feeling that can be relieved by shifting the positions of the legs or by stomping the feet on the floor. The knees can be strengthened by evenly building the muscles in the quadriceps and hamstrings. They will wear a surgical gown during the test, and be asked to urinate before the test starts.

Milok, 42 years: For instance, children develop three to eight colds or respiratory infections per year. Not getting mosquito bites while individuals are in the tropics is another possible way to avoid malaria. At that time, the drug had been used in Europe for over ten years for the same purpose.

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  • Kremer JM, Alarcon GS, Weinblatt ME et al. Clinical, laboratory, radiographic, and histopathologic features of methotrexate-associated lung injury in patients with rheumatoid arthritis: a multicenter study with literature review. Arthritis Rheum 1997;40(10):1829-37.
  • Angermaier A, Langner S, Kirsch M, et al. CT-angiographic collateralization predicts final infarct volume after intra-arterial thrombolysis for acute anterior circulation ischemic stroke. Cerebrovasc Dis 2011;31:177-84.
  • Roberts BW, Kilgannon JH, Chansky ME, et al. Multiple organ dysfunction after return of spontaneous circulation in postcardiac arrest syndrome. Crit Care Med. 2013;41: 1492-1501.