Angie Child Jelin, M.D.

  • Director, First Trimester Screening Program
  • Assistant Professor of Gynecology and Obstetrics

https://www.hopkinsmedicine.org/profiles/results/directory/profile/10001175/angie-jelin

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Theimageshrinks diabetic diet 1500 calorie diet menu cheap metformin 500 mg free shipping,butunevenly,distaljoints shrinking more slowly than proximal; this is the so called telescoping phenomenon. In common with such beliefs many patients on a fantasy level perceived the operation as a physical or sexual assault. Patients who fantasized the surgery as a sexual assault were supported in this belief by the colostomy stoma, a new opening in the front of the body. The bleeding from the stoma reinforced the fantasy of a second vagina because it was interpreted as comparable to menstruation. Mastectomy also results in relatively severe disturbance in self-concept and body image. Culture-Bound Disorders of Body Image Various culturally determined hysterical conditions have been described by Langness (1967). These conditions have in common a sudden, dramatic onset related in time to a psychosocial upset. Theyappeartobemore likely in those predisposed with histrionic (hysterical) personalities. Hamilton K and Waller G (1993) Media influences on body size estimation in anorexia and bulimia: an experimentalstudy. Lader M and Sartorius N (1968) Anxiety in patients with hysterical conversion symptoms. Mechanic D (1962) Students Under Stress: a Study in the Social Psychology of Adaption. Parsons T (1951) Illness and the role of the physician: a sociological perspective. Slater E and Glithero E (1965) A follow-up of patients diagnosed as suffering from hysteria. Inpsychiatry, pain can present as being heightened, markedly diminished or occurring in the absence of demonstrablecause. Another person believed herself to be suffering from venereal disease without having been exposed to the risk. Endogenousopiatesubstances(endorphins)havebeendiscov ered to inhibit nerve fibres reporting noxious events. The temptation to regard pain simply as any other sensation creates certain dilemmas. The experience of psychogenic pain has been associated with particular personality types (Engel,1959). Complaints of pain are common in neurotic disorder, especially with chronic anxiety or hysterical traits (Merskey,1965).

Syndromes

  • If the medication was prescribed for the patient
  • Statins
  • Fatigue
  • Abnormal heart valve, such as mitral valve prolapse
  • Uric acid level
  • Recent invasive heart procedures
  • Choking
  • Chest pain
  • Ask that the provider who has spent the most time with your child be present during the procedure.

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Conversely diabetes diet soda link discount metformin 850 mg otc, non-dihydropyridine calcium blockers such as verapamil and diltiazem, reduce the risk of overt nephropathy and improve size selectivity in glomeruli in diabetic nephropathy. Approximately after 5-7 days of prescription of reninangiotensin-aldosterone system inhibitors, creatinine levels should be controlled. Anti-proteinuric effects of renin-angiotensin-aldosterone system inhibitors is exacerbated with reducing sodium intake and taking other antihypertensive medications at the same time including diuretics and non-dihydropyridine calcium channel blockers. Even in patients with normal blood pressure those inhibitors reduce proteinuria with reduce intra-glomerular pressure and prevent progression of microalbuminuria to macroalbuminuria and clinical nephropathy. The results showed that aliskiren plus losartan compared with losartan alone resulted in more than twenty percent reduction in proteinuria without significant effect on systemic blood pressure (43). Spironolactone 50 mg a day were given in treatment group and another group were given placebo. Urine albumin to creatinine ratio up to 40% and systolic blood pressure 7 mmHg and diastolic blood pressure 3 mmHg were reduce in spironolactone group, whereas these parameters did not change in the placebo group (44). Drugs that increase serum potassium levels should be used with caution in these patients (46). Since beta blockers and calcium channel blockers inhibit renin secretion, it is recommended that these drugs are not taken in patients with hypoaldostronism hyporeninemic. If the serum potassium is less than 6 meq per liter, and the disease is asymptomatic, treatment usually do not require. If treatment require, mineralocorticoids (fludrocortison) or the sodium potassium exchange resins [kayexalate (sodium polystyrene)] can use. Both types of treatment in patients with cardiac decompensation may exacerbate previous failure (46). Due to the presence of hypertension, dyslipidemia and diabetes, there is a risk of nephropathy and its progression. Treatment of lipid disorders reduce microvascular (nephropathy and retinopathy) and macrovascular (coronary, cerebrovascular, peripheral vascular) complication in diabetic patients. Also urinary protein excretion rate and urine podocyte decreased in these patients significantly (48). Studies have shown that reducing protein intake in diabetic patients can reduce proteinuria and slow the progression of renal failure. Protein restriction can lead to decrease symptoms of uremia and delay need for dialysis. The possible mechanism of effect of protein restriction is reduced hyperfiltration in healthy nephron. American diabetes association recommends the maximum daily intake of protein is 0. Stop smoking In a study effects of smoking on renal complications in 359 type 1 diabetic patients were evaluated.

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However diabetic zombie apocalypse metformin 850 mg sale, decline in intellectual performance (Rogers, 1986), impairment in neuropsychological test batteries (Taylor and Abrams, 1984), sometimes a dementia-likesyndrome(LiddleandCrow,1984)andsubstantialmemorydeficit(Cutting,1985; McKenna etal. Furthermore, there is evidence of impairment of working memory and semantic memory, but procedural or implicit memory is intact. There may be altered states of consciousness such as a fugue, with impairedregistration. Thedegree of confabulation was related to problems in suppressing inappropriate responses and formal thoughtdisorder. Simple, momentary, or provoked confabulations, on the other hand, appear to be commonplace. Dissociative (Hysterical) Fugue the symptoms pertaining to dissociative (conversion) disorders (hysteria) in the International Classification of Diseases (World Health Organization, 1992) are of two types: conversion and dissociation. Thus the features of dissociative fugue are dissociative amnesia, purposeful travel beyond the usual everyday range and maintenance of basic self-care (World Health Organization,1992). Intellectual function had eventually returned to her premorbid, superior level by ninemonths. Recovered memory has been particularly associated with the return of memory for childhoodsexualabuse. Thetermfalse memory syndromecameintousein1992,whentheFalseMemorySyndrome Foundation was set up to represent the interests of parents who had been accused of abusing theirchildrensexually. They report sexual abuse in childhood, which it is claimed has been forgotten and recovered only in adult life, having been repressed from eight to 40 years. HirsteinW(2009)Confabulation: views from neuroscience, psychiatry, psychology, and philosophy. Everything in the world that is presented to us comes to us in space and time and we experience it only in these terms. Jasperscontinues: `If we want to bring these primary things home to ourselves in some neat phraseology we may say that they both represent the sundered existence of Being, separated from itself. A sense of time is clearly very central to the concept of self and its relationship with the outsideworld. This cluster of time characteristics is implicated at all levels of being, from the most physical of planetary movements via physiological rhythms to patterns of social organization, from the taken for granted via the invisible to the obvious, from the imposed via the lived to the culturally constructed. There can be no rejuvenation, no unknowing, no reconstitution of pollution back into aeroplane.

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There are two types of abnormal movement in schizophrenia: idiosyncratic voluntary movements or mannerisms and spontaneous involuntary movements diabetic diet crock pot recipes 500 mg metformin buy mastercard. Abnormality of the execution of movement may result from the internal experiences of the schizophrenicpatient. Thisalternation of cooperation and opposition produces the diffident, unpredictable behaviour of ambitendency. Automatic obedience denotes a condition in which the patient carries out every command in a literal,concretefashion,likeanautomaton. Rogersstudiedmotordisorders in 100 extremely chronic psychiatric in-patients, 59 women and 41 men, with a mean lengthofcurrentadmissionof42. Postureand tone, with a tendency to flexion associated with varying degrees of rigidity and typically affectingtheheadorneck. Conjugate deviation of the eyes, often up and laterally with deviation of the head in the samedirection. Disorderofeyemovements, tone, gait and blinking were recorded less commonly in the past. In addition to the description of abnormal movements above, overflow movements have beendescribed. However, the most conspicuous symptoms are in motor function: slowing of emotional and voluntary movement (Walton, 1985); muscular rigidity; akinesia; tremor; and disordersofgait,speechandposture. Acute dystonic reactions include a variety of intermittent or sustained muscular spasms and abnormal postures. The progressive dementia, with inertia and apathy, may be accompanied by irritability and occasional outbursts of excited behaviour. It is not known if this is truly an early symptom of the illness or part of the psychosocial reaction to this appalling and doom-laden condition. Theconditionstartsinchildhood, under the age of 16; there are multiple motor tics and unprovoked loud utterances that may amounttoshoutedobscenities. An interesting study compared adult sufferers with depressed adults and normal controls on measures of obsessionality, depression and anxiety (Robertson etal. It has often been commented that the incidence of catatonic schizophrenia has markedly declined. Negativism, as described above under motor disorders, may influence the behaviour of the patientsubstantially. There may be mannerisms and idiosyncrasies of behaviour as well as of single movements. Depressive facies and posture sometimes lead to diagnosis before the patient speaks. Whenshespokeof her son dying at the age of three, her body stiffened, the muscle tension in her face increased,asiftryingtostifleexpression,lacrimationincreased(thoughonlyjustperceptibly), and her voice rose in pitch and wavered.

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She is very skilled in the use of blades; after all juvenile diabetes signs toddler cheap 500 mg metformin overnight delivery, she has to shave her father, shave that soft paternal cheek under the completely empty paternal brow, which is now undimmed by any thought, unwrinkled by any will. Elfriede Jelinek (1988), the Piano Teacher Late at night I went into the bathroom and took the broken pieces of a razor blade which I had kept. As my writing to you comes to a close, the pain is so unbearable inside me that a force of such strength has driven me to inflict a physical pain on myself in the hope of appeasing the other. From3 to 5 per cent of patients, depending on how referrals are made, have measurable psychiatric disturbance. When these conditions affect the oral cavity, it is referred to as "burning mouth syndrome", a condition characterized by intraoral burning for which no medical or dental cause can be identified(Ducasseetal. Furthermorethatthereare augmented brain responses to thumb pressure, that is stimulation of an area remote from the vulva, demonstrable within the insula, dorsal midcingulate, posterior cingulate, and thalamus comparedtonormalcontrols. Pruritogenicitch(physio logical itch) is transmitted by dedicated afferent neurons much as is pain. The itch sensation in these conditions is analogous to neuropathic pain and overlaps with burning, aching and stinging sensations. Dahiya P, Kamal R, Kumar M, Niti, Gupta R and Chaudhary K (2013) Burning mouth syndrome and menopause. Donders G and Bellen G (2012) Characteristics of the pain observed in the focal vulvodynia syndrome. Feinmann C, Harris M and Cawley R (1984) Psychogenic facial pain: presentation and treatment. Markos A and DinsmoreW (2013) Persistent genital arousal and restless genitalia: sexual dysfunction or subtypeofvulvodynia NoordenbosW(1959)Pain: Problems Pertaining to the Transmission of Nerve Impulses Which Give Rise to Pain. Inanotherstudy,depressed affect was a major cause of somatic problems without physical pathology (Brenner, 1979). Feelings are also personal convictions, predictive forecasts and social sensibilities. In psychiatry, it is customary to limit its use to the expression of emotion as judged by the external manifestations that are associated with specific feelings, for example laughter, crying or fearful appearance. Itis the physical constitution that forms the tendency for developing, for example, a prolapsed intervertebral disc; in the mental realm, personality is closely associated with the type, quality anddirectionofmood. Simply, it posits that emotions are the result of self-awareness of physical and bodily changes in the presence of a stimulus. Common sense says, we lose our fortune, are sorry and weep; we meet a bear, are frightened and run; we are insulted by a rival, are angry and strike. Without the bodily states following on the perception, the latter would be purely cognitive in form, pale, colorless, destitute of emotional warmth.

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Patients with testicular seminoma may have modestly elevated levels of human chorionic gonadotrophin and of lactic dehydrogenase metabolic disease book generic metformin 500 mg otc. Due to low incidence and a high cure rate, advocacy of testicular self-examination and the impact of selfassessment are controversial. Pathology and genetics About 90% of testicular malignancies arise from germ cells and these tumours are classified as seminoma (40%). Ovarian germ cell tumours of young women share clinical features and treatment approaches with male germ cell tumours. All germ cell tumours are commonly associated with the presence of isochromosome 12p (an abnormal chromosome 12 with two identical short arms), a region which contains the gene for cyclin D2 [15]. The initiation of a germ cell tumour is associated with various aberrations in the normal developmental pathway of the germ cell. Management Current management of germ cell tumours should yield average cure rates in excess of 95%, and even 80% of patients with metastatic disease respond to chemotherapy, radiotherapy and surgery. The division of a precursor cell, the spermatocyte (4n), produces 4 sperm cells each with one set of chromosomes (1n). The fusion of egg and sperm to form the zygote doubles the number of chromosomes to the normal complement (2n). Aberrant development may produce a cell which has twice the normal chromosomal complement (4n). Seminoma Stage I disease, confined to the testis, is managed by post-operative radiotherapy to the retroperitoneal nodes which reduces risk of recurrence from about 20% to 2%. Patients who relapse either during surveillance or after radiation are reliably cured with chemotherapy or radiation at the time of relapse. Normal levels of alpha-fetoprotein, the presence of any human chorionic gonadotrophin or any lactic dehydrogenase are good prognostic factors. Patients with abdominal involve- Nonseminoma Patients with local nonseminoma confined to the testis should be offered either aggressive surveillance or nerve-sparing retroperitoneal lymph node dissection. Good prognostic factors include low levels of alpha-fetoprotein (<1000 ng/ml), human chorionic gonadotrophin (<5000 iu/L) and lactic dehydrogenase (<1. Approximately 30% of patients under surveillance will relapse and are reliably cured with chemotherapy. Patients with abdominal involvement of nonseminoma should receive retroperitoneal lymph node dissection (<2 cm disease) or primary chemotherapy (>2 cm disease). Those who undergo retroperitoneal lymph node dissection and are Cancers of the male reproductive tract 213 found to have positive nodes can consider two cycles of adjuvant chemotherapy (100% cure rate). Patients with nonseminoma who have normalized serum tumour markers and residual radiographic abnormalities should be considered for post-chemotherapy resection of residual disease. Teratoma (a malignant tumour that contains a variety of embryo-derived tissues, such as bone, muscle, cartilage, nerve, tooth buds) and persistent cancer are common findings in this setting. In contrast, patients with seminoma and residual masses after chemotherapy should be simply observed, as teratoma and residual cancer are not common findings in this situation. Patients with recurrent disease after chemotherapy still have the potential for cure.

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The majority of the fast twitch fibres and about a quarter of the slow twitch fibres in the intramural striated muscle of the human membranous urethral sphincter show positive staining for nitric oxide synthase in the sarcolemma 193 [193] diabetes type 1 mechanism 500 mg metformin buy with amex. Dense populations of acetylcholinesterase-positive nerve fibres are found associated with the striated 129 muscle fibres, with end plates on some of them [129]. Immunohistochemical studies have demonstrated the presence of nitric-oxide synthase containing nerve trunks and sparse fine nerve fibres running in the intramural striated muscle of the human membranous urethral sphincter, with the fine nerve fibres running parallel to and apparently innervating some striated muscle fibres [193]. Some nerve trunks containing tyrosine 193 hydroxylase immunoreactivity course through the striated muscle, but do not seem to be specifically associated with the striated fibres, and may just been route to smooth muscle, or innervating blood vessels. Recordings of contractile activity in rings of guinea-pig urethra have been made [211] but 211 the results were difficult to interpret because the activity included contraction of both striated and smooth muscle activity. In vivo studies have investigated the effects of nicotinic receptor blockade on the urethral 212 pressure in the pig [118], the dog [212] and in humans 118 204 [204], demonstrating a role of the striated muscle in generating resting urethral pressure. In the dog pudendal but not pelvic nerve stimulation produces contraction of the striated muscle. Electromyography can be used to record activity in the human striated sphincter b) Innervation the urethra has a complicated neuro-anatomy, receiving as it does input from both somatic and autonomic pathways. The rhabdosphincter receives somatic input from S2-S4 nerve roots via the pudendal nerve, and the pelvic nerves also enter the muscle [209, 210]. In the 209 210 cat, a triple innervation of the rhabdosphincter has been demonstrated histochemically (see [4]), with a somatic, 4 parasympathetic and sympathetic input. Evidence for a triple innervation in the human rhabdosphincter however is not strong, and it is likely that the functional innveration is somatic, although modulation through autonomic innervation cannot be ruled out. Note that most of the female striated muscle is slow twitch, whereas a significant proportion of the male fibres are fast twitch. Coughing, or other manoeuvres that increase intra-abdominal pressure produce a marked increase in the number of units firing. Abnormal activity can be recorded from patients with various disorders of urethral sphincter innervation 214 [214]. It seems likely that the slow twitch fibres will be more involved in the sustained generation of urethral pressure, and the larger component of these fibres in women may be a reflection of the shorter urethral length. As with the smooth muscle, it should be remembered that failure to switch off the tonic excitation of the striated muscle during micturition can result in detrusor sphincter dyssynergia, which can be a serious problem. The fast twitch fibres, with their greater fatigueability, have the properties necessary to mediate a rapid increase in urethral pressure to prevent stress incontinence. The lamina propria is lined proximally with a surface membrane consisting of transitional epithelium, and mucous glands have been described 215 along its length in the female urethra [215]. Between this and the smooth muscle layer is an extensive stroma surrounding a prominent vascular plexus. The urethral stroma has been less extensively studied than the bladder stroma, but it is known to contain primarily longitudinally arranged collagen fibres and elastin fibres 216 217]. In the dog, the stroma comprises almost 219 80% of the total volume in the proximal urethra, and contains abundant collagen fibrils and longitudinally orientated elastic fibres.

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Since most users can use hand geometry for access control diabetes mellitus kind metformin 500 mg purchase visa, few employees and visitors need to be processed outside the system. Swelling or injury to the hand, the presence of bandages or jewelry, and changes in weight that affect the dimensions of the hand can result in false readings. Vascular pattern recognition is a relatively new technology within the biometric access control industry and uses miniaturized infrared scanning technologies. Although these systems are less mature and may be more costly than other access control technologies, the maturity of vascular pattern recognition is increasing. The system produces grayscale images of the infrared pictures, which are converted to binary representations. Algorithms extract the useful features from the binary pictures and render them as a mathematical pattern or reference record, for matching during later verifications. The system then computes a template and compares it to the reference templates generated during enrollment. Users accept this type of biometric because it is non-intrusive, requires minimal contact with the skin, and takes less than one second to return a result even on large systems with several thousand registered users. Since these systems are relatively new to the market, they lack the long-term performance track records of older, more mature technologies. The operating principle behind these systems relies on blood flow through the veins. The iris is composed of measurable intricate details called striations, pits, and furrows. The quantity of unique information that can be measured in a single iris is much greater than in fingerprints. Iris recognition technology has traditionally been deployed in high-security situations when imaging can be done at a distance of less than three feet, and there is a need to search very large databases without incurring false matches. These systems are in use in a number of high profile applications, including airline passenger screening, prisoner recognition, and physical access to healthcare records. Available systems capture over 240 unique characteristics in formulating the template, which is over 10 times as much as other biometric systems. This means it is ideally suited for use in environments where gloves or other protective gear is used. Iris recognition technology can integrate easily into existing access control systems or operate as a stand-alone system. The illegal use of an iris pattern from an authorized user is unlikely and models of the iris that can fool the detector are almost impossible to produce. At death, iris tissue is one of the first body tissues to deteriorate; forensic pathologists use the iris as an accurate estimator of the time of death. Iris recognition uses a camera to capture an image of the iris and then converts that image into a template. The energy entering the eye is much less than when a person stands in sunlight or looks at an incandescent lamp. Various factors can affect an image of the iris including the camera angle, size of the pupil, angle of the head, or direction of the eye position.

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Insofar as this image depends on the new techniques and their corresponding ethos diabetic meds metformin 850 mg amex, it is supranational in character. But these very techniques are not culturally neutral; they assumed concrete shape within Western cultures and express a Western ethos. The image of a "natural death," a death which comes under medical care and finds us in good health and old age, is a quite recent ideal. At each stage of its evolution the image of natural death has elicited a new set of responses that increasingly acquired a medical character. The history of natural death is the history of the medicalization of the struggle against death. Nevertheless, the frequency of ecclesiastical prohibitions testifies that they were of little avail, and for a thousand years Christian churches and cemeteries remained dance floors. Dancing with the dead on their tombs was an occasion for affirming the joy of being alive and a source of many erotic songs and poems. In the shape of his body Everyman carries his own death with him and dances with it through his life. From dancing with dead ancestors over their graves, people turned to representing a world in which everyone dances through life embracing his own mortality. Death was represented, not as an anthropomorphic figure, but as a macabre self-consciousness, a constant awareness of the gaping grave. With Chaucer and Villon, death becomes as intimate and sensual as pleasure and pain. Primitive societies conceived of death as the result of an intervention by an alien actor. This somebody who causes death might be a neighbor who, in envy, looks at you with an evil eye, or it might be a witch, an ancestor who comes to pick you up, or the black cat that crosses your path. No figure of "a" death appears at the deathbed, just an angel and a devil struggling over the soul escaping from the mouth of the dying. Only during the fifteenth century were the conditions ripe for a change in this image,12 and for the appearance of what would later be called a "natural death. Death can now become an inevitable, intrinsic part of human life, rather than the decision of a foreign agent.

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Physical illness frequently precipitates a loss of the accustomed sense of well-being diabetes type 1 yahoo answers discount metformin 500 mg buy on line. If the heart, brain, liver, spleen, be misaffected, as they usually are, many inconveniences proceed from them, many diseases accompany. Trethowan (1979) considered that lowering of vitality is fundamental to the experience of depressiveillness. FeelingsDirectedTowardsPeople these may be disturbed in a number of different ways. Other free-floating affects occur, such as dread, restlessness,tension,gloom,despondency,euphoria,irritabilityandsoon. Abnormalities of Evaluation the relationship between cognitions and emotions is difficult to disentangle. In other words, it occurs in some patients but not in others and dissociates from impairment of face recognitionperse. Psychic retardation is experienced subjectively as an inability to fulfil normal obligations, as loss of coping. Agitation and purposeless restlessness add to the discomfort and to the inability of the depressed person to achieve anything. Concentration, application and decision making become difficult, painful and sometimes impossible. Physical retardation may become the focus for hypochondriacal beliefs about the body:`I am constipated. Forallthat goes wrong around him he takes personal blame; this may be of delusional intensity. Alvarez (1971) has written a detailed study of suicide from a literary point of view. He is concerned with the background and the reasons for suicide andattemptedsuicideinmanywell-knownwriters,especiallypoets. Seneca, the final authority on the subject, pointed out disdainfully that the exits are everywhere: each precipice and river, each branch of each tree, every vein in your body will set you free. An example of depression associated with the threat of loss of a loved object was a taxi driver who owned his own car, which was the only thing he valued in life. Not surprisingly, this state is often associated with suicidal ideas and impulses, and there is an increased mortality from suicide and other causes in the six months subsequenttobereavement(Parkesetal. Parkes (1976) discriminates between the subjective experience of external loss and internal change. It has become conventional to refer to all but the most severe cases as sufferingfromhypomania. In pure form, it is characterized by excessive cheerfulness, rapid train and association of thoughtandoveractivity. She was no sooner announced than every missile and instrument of attack was carefully removed out of her way.

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References

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  • Bosso JA, Pearson RE. Sugar content of selected liquid medicinals. Diabetes 1973;22:776.
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  • Su LK, Kinzler KW, Vogelstein B, et al. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 1992;256(5057):668-670.
  • Tezon JG, Ramella E, Cameo MS, et al: Immunochemical localization of secretory antigens in the human epididymis and their association with spermatozoa, Biol Reprod 32:591n597, 1985.